IMV Provides Update on Progress of its DPX-RSV Program
New data from a preclinical study highlighted the effects of two potential approaches to preventing RSV, comparing a single dose bovine version of DPX-RSV to a two-dose conventional investigational bovine RSV vaccine. Researchers found that IMV’s vaccine candidate yielded strong antigen-specific immune responses and a protective effect on disease pathology. The degree of protection was comparable between the two vaccine candidates.
“While we remain focused on advancing our immuno-oncology clinical program, it is our intention to partner our DPX technology in other applications, including infectious diseases,” said
Conventional RSV vaccine candidates target either the F or G proteins of the virus, providing protection by neutralizing the RSV virus. Clinical measures of efficacy focus on the amount of neutralizing antibodies in the bloodstream.i,[ii] DPX-RSV works differently; it targets the SH viral ectodomain of the RSV virus, and, instead of neutralizing the virus, it enables the immune system to recognize and destroy infected cells. Because there are no neutralizing antibodies resulting from the DPX-RSV MOA, a different clinical assessment is required to determine the vaccine candidate’s protective effect.
In this study, researchers compared the effects of both the IMV and conventional RSV vaccine approaches among bovines with known RSV infections (The bovine animal model is considered an optimal model of RSV infection.)iii,[iv] Researchers administered one dose of DPX-bRSV to one cohort; the second received two doses of a subunit RSV bovine vaccine. Researchers measured immune response with an antibody titer test, and assessed disease pathology with a lung lesion score and other clinical parameters (such as body temperature changes).
They found SH antibodies in 14 of the 15 subjects that received DPX-bRSV, and the improvements observed in disease pathology were comparable between the two cohorts. These were the first bovine animal health data to directly correlate the vaccine-induced immune response against IMV’s novel RSV target - the SH viral protein– with measures of disease protection.
“We engaged in these studies to demonstrate that the unique immune response induced by DPX-RSV could provide protection against RSV infections,” said
IMV is also collaborating on additional studies to further demonstrate the validity of DPX-RSV’s novel MOA. These include an academic collaboration to assess the levels of SH-specific antibodies present in the elderly population following RSV infections, and an ongoing collaboration with an undisclosed partner on the development of a SHe human monoclonal antibody.
IMV and its research partners plan to present complete data for these ongoing studies at an upcoming scientific conference or publish the results in a peer-reviewed scientific journal.
Respiratory syncytial virus (RSV) is a common virus that infects the lungs and breathing passages. While it usually leads to mild, cold-like symptoms, it can be severe in elderly adults, infants, and individual with compromised immune systems. It is second only to influenza as the most commonly identified cause of viral pneumonia in older persons. Globally, it is estimated that 64 million cases of RSV infection occur annually in all age groups, with 160,000 deaths. There is no vaccine currently available to prevent RSV.
DPX-RSV is IMV’s prophylactic, small B-cell epitope peptide vaccine candidate designed specifically to address the unmet medical needs in respiratory syncytial virus (RSV). DPX-RSV targets the SH antigen of RSV, which may provide additional immunogenic benefit over traditional approaches for high-risk populations, including infants and the elderly.v Scientists from
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i RSV Vaccine and mAb Snapshot. (2018, September) Retrieved from URL: https://www.path.org/resources/rsv-vaccine-and-mab-snapshot
ii Mazur NI, Higgins D., Nunes MC., Melero JA., Langedijk AC., Horsley N., . . .
iii Taylor G. “Animal models of respiratory syncytial virus infection.” Vaccine 2017 Jan 11;35(3):469-480. doi: 10.1016/j.vaccine.2016.11.054. Retrieved via URL: http://www.ncbi.nlm.nih.gov/pubmed/27908639
iv Taylor, G. “Bovine model of respiratory syncytial virus infection.” Current Topics in Microbiology and Immunology. 2013;372:327-45. doi: 10.1007/978-3-642-38919-1_16. Retrieved via URL: http://www.ncbi.nlm.nih.gov/pubmed/24362697
v Schepens, Bert, Michael Schotsaert, and
vi MS. Schepens et al, EMBO Mol Med 2014 6:1436-1454
Source: IMV Inc.